Molting cycle process

Across TCGA patient cohorts, RNA activity of the Molting cycle process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EGFR, SYNE1_S460, and SYNE1_S8305, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Molting cycle process activity versus EGFR in GBM (Pearson r = -0.00).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	EGFR →	+1.149	+0.219	<.001	<.001	3	5
LSCC	SYNE1_S460 →	-0.686	-0.162	<.001	.004	3	4
LSCC	SYNE1_S8305 →	-0.686	-0.162	<.001	.004	3	4
GBM	POLR1E →	+0.341	+0.202	<.001	<.001	3	4
UCEC	TBC1D1 →	-0.405	-0.412	.003	.001	3	4
HNSC	CYLD →	-0.257	-0.270	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022404 vs EGFR — GBM

Explore this scatter interactively →