Molting cycle process

Across TCGA cell cohorts, RNA activity of the Molting cycle process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL13RA1, POLE, and RPS27L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Molting cycle process activity versus IL13RA1 in BONE (Pearson r = -0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	IL13RA1 →	-2.270	-0.376	.008	.001	3	5
LARGE_INTESTINE	POLE →	+0.779	+0.179	<.001	.002	3	5
LUNG_NSCLC_LUSC	RPS27L →	-2.055	-0.369	.004	<.001	3	5
CNS	TMEM9B →	-0.552	-0.404	.003	.006	3	5
OESOPHAGUS	TBC1D12 →	-0.835	-0.331	.001	.002	3	4
STOMACH	PGPEP1 →	-1.498	-0.206	.001	.005	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022404 vs IL13RA1 — BONE

Explore this scatter interactively →