Negative adaptation of signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative adaptation of signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ESF1, PDCD11, and TSR1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative adaptation of signaling pathway activity versus ESF1 in LSCC (Pearson r = -0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ESF1 →	-0.393	-0.064	<.001	<.001	3	7
LSCC	PDCD11 →	-0.367	-0.078	<.001	<.001	3	7
BRCA	TSR1 →	-0.328	-0.037	.001	<.001	3	6
LSCC	WDR43 →	-0.361	-0.067	<.001	<.001	3	6
LSCC	XPO5 →	-0.679	-0.082	<.001	<.001	3	6
BRCA	BMS1 →	-0.361	-0.037	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022401 vs ESF1 — LSCC

Explore this scatter interactively →