Negative adaptation of signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative adaptation of signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FGD2, PRKCB, and MFNG, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative adaptation of signaling pathway activity versus FGD2 in LSCC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FGD2 →	+0.999	+0.168	<.001	<.001	3	6
GBM	PRKCB →	+0.757	+0.465	.001	.002	3	6
LSCC	MFNG →	+0.850	+0.194	<.001	<.001	3	6
LSCC	ZNF831 →	+0.888	+0.168	<.001	<.001	3	6
LSCC	RAB37 →	+0.737	+0.183	<.001	<.001	3	6
LSCC	CD28 →	+0.917	+0.165	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022401 vs FGD2 — LSCC

Explore this scatter interactively →