Negative adaptation of signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative adaptation of signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GABPB1, ARHGAP9, and ZFHX4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GABPB1 grouped by Negative adaptation of signaling pathway-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	GABPB1 →	+0.428	+0.322	<.001	<.001	3	5
PANCREAS	ARHGAP9 →	+0.246	+0.207	.008	.001	2	5
OESOPHAGUS	ZFHX4 →	-0.190	-0.218	<.001	<.001	3	4
LUNG_SCLC	HSPD1 →	+0.452	+0.135	<.001	.004	3	4
KIDNEY	SOX4 →	+0.264	+0.181	.001	.004	3	4
BREAST	USP17L1 →	+0.172	+0.117	.007	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GABPB1 by Negative adaptation of signaling pathway activity — URINARY_TRACT

Explore this box plot interactively →