Regulation of opsin-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of opsin-mediated signaling pathway pathway is significantly associated with the drug response of multiple features, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are FGFR_0939, AZD7969, and PAK_5339, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FGFR_0939 grouped by Regulation of opsin-mediated signaling pathway-low versus -high activity in BLOOD_Leukemia.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FGFR_0939 →	-0.549	-1.788	.045	.004	3	1
BLOOD_Leukemia	AZD7969 →	-0.719	-1.835	.013	.001	3	1
BLOOD_Leukemia	PAK_5339 →	-0.530	-1.835	.015	.001	3	1
BLOOD_Leukemia	Fulvestrant →	-0.465	-1.788	.044	.004	3	1
BLOOD_Leukemia	50869 →	-0.490	-1.724	.039	.001	3	1
BLOOD_Leukemia	Linifanib →	-0.910	-1.788	.037	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FGFR_0939 by Regulation of opsin-mediated signaling pathway activity — BLOOD_Leukemia

Explore this box plot interactively →