Corpus callosum development

Across TCGA patient cohorts, RNA activity of the Corpus callosum development pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CEP41, IFT22, and SHANK3_S979, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Corpus callosum development activity versus CEP41 in OV (Pearson r = 0.06).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CEP41 →	+0.265	+0.032	.008	.009	3	5
BRCA	IFT22 →	+0.271	+0.031	<.001	<.001	3	5
CCRCC	SHANK3_S979 →	-0.735	-0.040	.002	.004	3	4
UCEC	TMEM30A →	-0.378	-0.077	.005	<.001	3	4
OV	RHBDF2_S385 →	-0.646	-0.057	.008	<.001	3	4
COAD	PGGT1B →	-0.211	-0.022	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022038 vs CEP41 — OV

Explore this scatter interactively →