Corpus callosum development

Across TCGA patient cohorts, RNA activity of the Corpus callosum development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL2RG, B3GNT3, and RNF170, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Corpus callosum development activity versus IL2RG in BRCA (Pearson r = -0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IL2RG →	-0.820	-0.511	<.001	.003	3	4
BRCA	B3GNT3 →	-1.233	-0.601	<.001	<.001	3	4
BRCA	RNF170 →	+0.516	+0.645	.002	.001	3	3
BRCA	IGHA1 →	-1.638	-0.496	<.001	<.001	3	3
UCEC	IGHJ1 →	-1.653	-0.614	.003	.006	3	3
BRCA	DHRS9 →	-0.411	-0.401	.004	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022038 vs IL2RG — BRCA

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