Corpus callosum development

Across TCGA cell cohorts, RNA activity of the Corpus callosum development pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAH, SOS1, and DYRK1A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Corpus callosum development activity versus FAH in SOFT_TISSUE (Pearson r = -0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	FAH →	-1.107	-1.161	.009	<.001	3	5
SOFT_TISSUE	SOS1 →	+0.867	+1.378	.002	<.001	3	5
LUNG_NSCLC_LUSC	DYRK1A →	+0.653	+1.307	.008	<.001	3	5
LUNG_SCLC	SMIM8 →	+0.706	+1.195	.004	<.001	3	5
BLOOD_Lymphoma	BTBD2 →	+0.978	+1.039	.001	<.001	3	5
LUNG_NSCLC_LUAD	CTSD →	-1.408	-0.849	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022038 vs FAH — SOFT_TISSUE

Explore this scatter interactively →