Metencephalon development

Across TCGA patient cohorts, RNA activity of the Metencephalon development pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP1B_S1965, MYO1C_S408, and HNRNPLL, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Metencephalon development activity versus MAP1B_S1965 in LSCC (Pearson r = 0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MAP1B_S1965 →	+1.028	+0.039	<.001	<.001	3	6
GBM	MYO1C_S408 →	-0.474	-0.056	<.001	<.001	3	6
HNSC	HNRNPLL →	+0.185	+0.041	<.001	<.001	3	5
OV	ACIN1_S710 →	-0.515	-0.043	<.001	<.001	3	5
COAD	RSL1D1_S427 →	-1.089	-0.026	<.001	<.001	3	5
COAD	SRRM2_S1112 →	-1.185	-0.022	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022037 vs MAP1B_S1965 — LSCC

Explore this scatter interactively →