Metencephalon development

Across TCGA patient cohorts, RNA activity of the Metencephalon development pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLIN1_S497, BAZ1B_S361, and SETD1A_S470, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Metencephalon development activity versus PLIN1_S497 in PDAC (Pearson r = -0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PLIN1_S497 →	-1.629	-0.753	<.001	<.001	3	4
UCEC	BAZ1B_S361 →	+2.579	+1.970	.001	<.001	3	3
OV	SETD1A_S470 →	+0.812	+0.205	<.001	<.001	3	3
LUAD	SETD1B_T381 →	+0.399	+0.159	<.001	<.001	3	3
LSCC	ATRX_S1996 →	+0.539	+0.138	<.001	<.001	3	3
OV	UBE2K →	-0.253	-0.174	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022037 vs PLIN1_S497 — PDAC

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