Metencephalon development

Across TCGA cell cohorts, RNA activity of the Metencephalon development pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLDN1, FZD3, and GBP5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CLDN1 grouped by Metencephalon development-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CLDN1 →	-1.978	-0.259	.003	.002	3	5
BLOOD_Leukemia	FZD3 →	+1.215	+0.462	<.001	.009	3	4
BREAST	GBP5 →	-0.365	-0.458	.002	.002	3	4
BONE	DKK3 →	-5.374	-0.256	.001	<.001	3	4
LUNG_NSCLC_LUAD	PLA2G4C →	-1.035	-0.520	.004	.005	3	4
SKIN	PLAUR →	-1.770	-0.326	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CLDN1 by Metencephalon development activity — LARGE_INTESTINE

Explore this box plot interactively →