Telencephalon glial cell migration

Across TCGA patient cohorts, RNA activity of the Telencephalon glial cell migration pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HIP1, THBS2, and ISG20, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Telencephalon glial cell migration activity versus HIP1 in BRCA (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HIP1 →	+0.277	+0.039	.001	<.001	3	7
BRCA	THBS2 →	+0.961	+0.036	<.001	<.001	3	7
BRCA	ISG20 →	-0.483	-0.029	<.001	<.001	3	6
BRCA	SRPX2 →	+0.829	+0.043	<.001	<.001	3	6
GBM	EPN2 →	+0.306	+0.046	.003	.007	3	6
HNSC	CD38 →	-0.647	-0.049	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022030 vs HIP1 — BRCA

Explore this scatter interactively →