Telencephalon glial cell migration

Across TCGA cell cohorts, RNA activity of the Telencephalon glial cell migration pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDLIM7, LAMP2, and GPD1L, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Telencephalon glial cell migration activity versus PDLIM7 in CNS (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PDLIM7 →	+0.973	+0.266	.004	.005	1	9
STOMACH	LAMP2 →	+1.523	+0.701	.001	<.001	3	7
BREAST	GPD1L →	-1.852	-0.409	<.001	<.001	3	7
SKIN	HSPA9 →	-0.526	-0.236	.004	.002	3	7
SKIN	EGFR →	+2.484	+0.309	.009	<.001	2	7
STOMACH	ITGA5 →	+3.561	+0.640	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022030 vs PDLIM7 — CNS

Explore this scatter interactively →