Tangential migration from the subventricular zone to the olfactory bulb

Across TCGA patient cohorts, RNA activity of the Tangential migration from the subventricular zone to the olfactory bulb pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RBSN, SLIT2, and FERMT2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tangential migration from the subventricular zone to the olfactory bulb activity versus RBSN in GBM (Pearson r = 0.08).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RBSN →	+0.236	+0.118	<.001	<.001	3	9
PDAC	SLIT2 →	+0.461	+0.075	<.001	<.001	3	8
BRCA	FERMT2 →	+0.484	+0.059	<.001	<.001	3	8
BRCA	HSPA12B →	+0.522	+0.065	<.001	<.001	3	8
BRCA	KANK2 →	+0.498	+0.057	<.001	<.001	3	8
BRCA	LUM →	+0.913	+0.069	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022028 vs RBSN — GBM

Explore this scatter interactively →