Tangential migration from the subventricular zone to the olfactory bulb

Across TCGA patient cohorts, RNA activity of the Tangential migration from the subventricular zone to the olfactory bulb pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRRK2, CSF3R, and JAML, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tangential migration from the subventricular zone to the olfactory bulb activity versus LRRK2 in LUAD (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	LRRK2 →	+1.668	+0.510	<.001	<.001	2	7
LSCC	CSF3R →	+1.075	+0.535	<.001	<.001	3	5
LSCC	JAML →	+0.695	+0.575	<.001	<.001	3	5
LSCC	ACKR1 →	+1.479	+0.724	<.001	<.001	3	5
LSCC	CASP4LP →	+0.519	+0.692	<.001	<.001	3	5
LSCC	FCN1 →	+0.661	+0.681	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022028 vs LRRK2 — LUAD

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