Tangential migration from the subventricular zone to the olfactory bulb

Across TCGA cell cohorts, RNA activity of the Tangential migration from the subventricular zone to the olfactory bulb pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLF5, TNRC6A, and MYH9, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KLF5 grouped by Tangential migration from the subventricular zone to the olfactory bulb-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	KLF5 →	-1.954	-0.411	<.001	<.001	3	3
KIDNEY	TNRC6A →	-1.103	-0.311	<.001	.001	3	3
CNS	MYH9 →	-1.707	-0.821	.003	.009	3	3
CNS	APOL6 →	-1.283	-0.963	.003	.008	3	3
URINARY_TRACT	MID1 →	-1.912	-0.240	.004	<.001	3	3
BLOOD_Leukemia	DNAH10 →	+0.198	+0.253	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KLF5 by Tangential migration from the subventricular zone to the olfactory bulb activity — KIDNEY

Explore this box plot interactively →