Tangential migration from the subventricular zone to the olfactory bulb

Across TCGA cell cohorts, RNA activity of the Tangential migration from the subventricular zone to the olfactory bulb pathway is significantly associated with the drug response of multiple features, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are Afatinib, Crizotinib, and ICL1100013, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, Afatinib grouped by Tangential migration from the subventricular zone to the olfactory bulb-low versus -high activity in CNS.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Afatinib →	+0.698	+0.122	.001	.037	2	1
CNS	Crizotinib →	+1.080	+0.122	.049	.037	2	1
CNS	ICL1100013 →	+1.393	+0.122	.002	.037	2	1
CNS	AZD7969 →	+0.796	+0.122	.046	.037	2	1
CNS	IGFR_3801 →	+0.746	+0.122	.006	.037	2	1
CNS	JAK3_7406 →	+0.940	+0.122	.014	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Afatinib by Tangential migration from the subventricular zone to the olfactory bulb activity — CNS

Explore this box plot interactively →