Interkinetic nuclear migration

Across TCGA patient cohorts, RNA activity of the Interkinetic nuclear migration pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FAM172A, TBC1D2B, and TIMM23, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Interkinetic nuclear migration activity versus FAM172A in BRCA (Pearson r = 0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FAM172A →	+0.389	+0.053	<.001	<.001	3	7
LSCC	TBC1D2B →	+0.277	+0.065	<.001	<.001	3	5
BRCA	TIMM23 →	-0.277	-0.027	<.001	.006	3	5
BRCA	TIMM44 →	-0.362	-0.057	<.001	<.001	3	5
BRCA	CHKB →	+0.210	+0.042	.001	<.001	3	5
BRCA	CKAP2 →	-0.552	-0.048	.003	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022027 vs FAM172A — BRCA

Explore this scatter interactively →