Interkinetic nuclear migration

Across TCGA patient cohorts, RNA activity of the Interkinetic nuclear migration pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POGLUT3, IFITM3P2, and PCM1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Interkinetic nuclear migration activity versus POGLUT3 in GBM (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	POGLUT3 →	+0.513	+0.733	.005	.001	3	4
LUAD	IFITM3P2 →	-0.663	-0.854	<.001	.003	3	4
UCEC	PCM1 →	+0.368	+0.472	.002	.001	3	4
LSCC	ADGRE3 →	-0.451	-0.649	.006	.001	3	4
OV	TRBV14 →	-0.519	-0.597	.007	.006	3	3
LSCC	ARHGEF10 →	+0.197	+0.565	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022027 vs POGLUT3 — GBM

Explore this scatter interactively →