Interkinetic nuclear migration

Across TCGA cell cohorts, RNA activity of the Interkinetic nuclear migration pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCM1, MAD2L1BP, and DNAI4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Interkinetic nuclear migration activity versus PCM1 in LUNG_SCLC (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PCM1 →	+0.883	+0.677	.002	.008	2	6
OVARY	MAD2L1BP →	+0.608	+1.344	.008	.006	2	5
LARGE_INTESTINE	DNAI4 →	+1.308	+0.469	.006	<.001	3	4
BREAST	ELOA3BP →	+0.043	+0.826	.008	.001	3	3
URINARY_TRACT	RPL5 →	+0.944	+0.358	.009	.001	3	3
URINARY_TRACT	CYB561 →	-1.678	-0.358	.008	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022027 vs PCM1 — LUNG_SCLC

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