Neural plate anterior/posterior regionalization

Across TCGA patient cohorts, RNA activity of the Neural plate anterior/posterior regionalization pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MYL6, TFAM, and TFAP4_S124, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neural plate anterior/posterior regionalization activity versus MYL6 in OV (Pearson r = -0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MYL6 →	-0.316	-0.079	<.001	<.001	3	7
GBM	TFAM →	+0.352	+0.089	<.001	<.001	3	6
COAD	TFAP4_S124 →	+0.320	+0.054	.001	<.001	3	6
BRCA	UQCC2 →	+0.419	+0.069	<.001	<.001	3	6
HNSC	ARPC2 →	-0.235	-0.105	<.001	<.001	3	6
LSCC	MSN →	-0.349	-0.123	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021999 vs MYL6 — OV

Explore this scatter interactively →