Neural plate anterior/posterior regionalization

Across TCGA patient cohorts, RNA activity of the Neural plate anterior/posterior regionalization pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LIN7A, PUM1, and ZNF160, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neural plate anterior/posterior regionalization activity versus LIN7A in UCEC (Pearson r = -0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LIN7A →	-0.887	-0.620	.001	.001	3	3
UCEC	PUM1 →	+0.301	+0.655	.004	<.001	2	4
BRCA	ZNF160 →	+0.527	+0.400	.001	.007	3	3
LUAD	GABARAPL2 →	+0.234	+0.514	.008	.001	3	3
CCRCC	MTCYBP43 →	+0.199	+0.327	.003	.005	3	3
CCRCC	CYBRD1 →	+0.635	+0.386	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021999 vs LIN7A — UCEC

Explore this scatter interactively →