Olfactory lobe development

Across TCGA patient cohorts, RNA activity of the Olfactory lobe development pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CTNNA1, RIN3, and UNC13D, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Olfactory lobe development activity versus CTNNA1 in CCRCC (Pearson r = -0.08).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CTNNA1 →	-0.339	-0.040	<.001	.001	3	6
LSCC	RIN3 →	+0.246	+0.053	.007	<.001	3	6
PDAC	UNC13D →	+0.288	+0.037	<.001	<.001	3	6
CCRCC	FMNL1 →	+0.355	+0.033	.003	.007	3	6
COAD	MPO →	+0.656	+0.019	.005	.006	3	6
CCRCC	ERBB3_S686 →	-0.530	-0.032	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021988 vs CTNNA1 — CCRCC

Explore this scatter interactively →