Olfactory lobe development

Across TCGA patient cohorts, RNA activity of the Olfactory lobe development pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLL1, CDKN3, and CENPK, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Olfactory lobe development activity versus TLL1 in LSCC (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TLL1 →	+0.782	+0.667	<.001	<.001	3	5
LSCC	CDKN3 →	-1.006	-0.536	<.001	<.001	3	5
LSCC	CENPK →	-0.803	-0.568	<.001	.003	3	4
LSCC	CLDN5 →	+0.476	+0.491	.001	<.001	3	4
OV	PDE2A →	+0.530	+0.240	.002	.001	3	4
LSCC	KANK3 →	+0.479	+0.736	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021988 vs TLL1 — LSCC

Explore this scatter interactively →