Cerebral cortex development

Across TCGA patient cohorts, RNA activity of the Cerebral cortex development pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EDIL3, STON1, and MYL9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cerebral cortex development activity versus EDIL3 in CCRCC (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	EDIL3 →	+1.515	+0.805	<.001	<.001	3	5
CCRCC	STON1 →	+0.720	+0.758	<.001	.002	3	5
OV	MYL9 →	+0.946	+0.272	<.001	.005	3	4
BRCA	ACTA2 →	+0.943	+0.394	<.001	<.001	3	4
COAD	CALD1 →	+0.726	+0.635	<.001	<.001	3	4
CCRCC	TAGLN →	+1.134	+0.781	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021987 vs EDIL3 — CCRCC

Explore this scatter interactively →