Cerebral cortex development

Across TCGA cell cohorts, RNA activity of the Cerebral cortex development pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS14, CLDN3, and SLC20A2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPS14 grouped by Cerebral cortex development-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	RPS14 →	-0.916	-0.205	.007	.007	3	4
URINARY_TRACT	CLDN3 →	+2.802	+0.203	.002	.002	3	4
URINARY_TRACT	SLC20A2 →	+1.155	+0.250	<.001	.001	3	4
KIDNEY	CDC37 →	-0.529	-0.283	.006	.003	3	4
LUNG_NSCLC_LUAD	C16orf74 →	-1.207	-0.131	.005	.008	3	4
OESOPHAGUS	RPS23 →	-0.555	-0.147	.002	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPS14 by Cerebral cortex development activity — OESOPHAGUS

Explore this box plot interactively →