Pituitary gland development

Across TCGA patient cohorts, RNA activity of the Pituitary gland development pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are XRCC1_S241, ADH5, and LIN54_S635, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pituitary gland development activity versus XRCC1_S241 in OV (Pearson r = -0.14).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	XRCC1_S241 →	-0.646	-0.053	.008	.001	3	6
OV	ADH5 →	+0.405	+0.036	<.001	.002	3	5
OV	LIN54_S635 →	-0.830	-0.057	.001	<.001	3	5
LSCC	CDK1 →	-0.463	-0.039	.006	.008	2	6
PDAC	FLNB →	+0.397	+0.044	<.001	.001	2	6
BRCA	RIF1_S2348 →	-1.243	-0.048	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021983 vs XRCC1_S241 — OV

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