Pituitary gland development

Across TCGA patient cohorts, RNA activity of the Pituitary gland development pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMO, ADAM1B, and RFTN2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pituitary gland development activity versus SMO in LSCC (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SMO →	+0.760	+0.779	<.001	.001	3	4
LSCC	ADAM1B →	+0.754	+0.749	.005	.003	3	4
GBM	RFTN2 →	+0.733	+0.635	<.001	.002	3	4
OV	NR2F2 →	+0.596	+0.689	.002	.001	3	4
GBM	GLG1 →	+0.227	+0.454	.005	.005	3	4
HNSC	ARHGEF26 →	+1.258	+0.751	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021983 vs SMO — LSCC

Explore this scatter interactively →