Pituitary gland development

Across TCGA cell cohorts, RNA activity of the Pituitary gland development pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OGDH, SCUBE2, and NET1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OGDH grouped by Pituitary gland development-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OGDH →	+0.439	+1.735	<.001	<.001	3	3
LUNG_SCLC	SCUBE2 →	+0.350	+1.954	.001	<.001	3	2
LUNG_NSCLC_LUSC	NET1 →	-0.224	-1.987	.005	<.001	3	2
LUNG_NSCLC_LUSC	FAM185BP →	-0.273	-2.051	.001	<.001	3	2
LUNG_SCLC	TCF20 →	-0.231	-1.307	.001	.001	3	2
LARGE_INTESTINE	PARP4 →	-0.224	-0.228	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OGDH by Pituitary gland development activity — LUNG_SCLC

Explore this box plot interactively →