Pituitary gland development

Across TCGA cell cohorts, RNA activity of the Pituitary gland development pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BBS4, INTS2, and ARSK, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pituitary gland development activity versus BBS4 in LARGE_INTESTINE (Pearson r = -0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BBS4 →	-0.897	-0.257	.001	.001	2	5
PANCREAS	INTS2 →	-0.664	-0.347	.002	.008	3	3
BLOOD_Myeloma	ARSK →	-1.013	-1.886	<.001	<.001	3	3
BLOOD_Myeloma	DENND1C →	+3.603	+1.886	.001	<.001	3	3
BLOOD_Myeloma	HLA-DOB →	+2.480	+1.886	.004	<.001	3	3
BLOOD_Myeloma	GALC →	-2.283	-1.886	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021983 vs BBS4 — LARGE_INTESTINE

Explore this scatter interactively →