Hypothalamus cell differentiation

Across TCGA patient cohorts, RNA activity of the Hypothalamus cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are P4HA2, SERPINH1, and TUBB6, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hypothalamus cell differentiation activity versus P4HA2 in CCRCC (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	P4HA2 →	+0.614	+0.075	<.001	<.001	3	8
BRCA	SERPINH1 →	+0.516	+0.081	.001	<.001	3	7
OV	TUBB6 →	+0.568	+0.129	<.001	<.001	3	7
LSCC	BMP1 →	+0.412	+0.089	.002	.002	3	7
GBM	PLOD1 →	+0.469	+0.069	<.001	.002	3	7
CCRCC	PLOD2 →	+0.810	+0.072	.004	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021979 vs P4HA2 — CCRCC

Explore this scatter interactively →