Hypothalamus cell differentiation

Across TCGA cell cohorts, RNA activity of the Hypothalamus cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RHOC, TTLL12, and PRICKLE2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RHOC grouped by Hypothalamus cell differentiation-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	RHOC →	-2.875	-1.756	<.001	.002	3	5
BONE	TTLL12 →	+1.170	+1.981	<.001	<.001	3	4
BONE	PRICKLE2 →	-2.548	-1.940	.005	<.001	3	4
STOMACH	PTPN23 →	-0.534	-0.879	.002	.005	3	4
BONE	ASPHD1 →	-2.538	-1.454	<.001	<.001	3	4
BONE	CHEK2 →	+1.242	+1.701	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RHOC by Hypothalamus cell differentiation activity — BONE

Explore this box plot interactively →