Telencephalon regionalization

pathway activity — cross-omics
GO:0021978Cross-omicsPROTEIN-MS → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Telencephalon regionalization pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TRA2B_S276, TRA2B_S278, and DEK_S32, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
HNSCTRA2B_S276 →+1.653+1.183.002.00135
HNSCTRA2B_S278 →+1.653+1.183.002.00135
OVDEK_S32 →+1.033+0.545.002.00135
UCECMDC1 →+0.303+0.543<.001<.00135
COADSRRM2_S1916 →+1.077+0.890<.001<.00134
UCECSRRM2_T903 →+1.234+0.779<.001<.00134
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration