Anterior commissure morphogenesis

Across TCGA patient cohorts, RNA activity of the Anterior commissure morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NFIB, HABP4, and KLHL23, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Anterior commissure morphogenesis activity versus NFIB in UCEC (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NFIB →	+1.213	+0.532	<.001	.006	3	5
GBM	HABP4 →	+0.436	+0.649	.002	.004	3	4
GBM	KLHL23 →	+0.704	+0.610	<.001	<.001	3	4
CCRCC	SLC1A2 →	+0.230	+0.770	<.001	<.001	3	4
BRCA	FBXO30 →	+0.550	+0.568	<.001	.001	2	4
CCRCC	THRA →	+0.605	+0.746	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021960 vs NFIB — UCEC

Explore this scatter interactively →