Anterior commissure morphogenesis

Across TCGA cell cohorts, RNA activity of the Anterior commissure morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPS22, TAF9, and MCOLN3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MRPS22 grouped by Anterior commissure morphogenesis-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	MRPS22 →	-0.903	-1.310	<.001	.002	3	4
KIDNEY	TAF9 →	-0.805	-1.314	.005	.009	3	4
CNS	MCOLN3 →	+2.385	+1.917	.008	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	PCOLCE2 →	+2.718	+1.543	<.001	.003	3	3
UPPER_AERODIGESTIVE_TRACT	PRDM11 →	+1.168	+1.712	.004	.006	3	3
STOMACH	DNAJC7 →	-0.732	-1.461	.005	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MRPS22 by Anterior commissure morphogenesis activity — STOMACH

Explore this box plot interactively →