Corticospinal tract morphogenesis

Across TCGA patient cohorts, RNA activity of the Corticospinal tract morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HMCN1, SERPINA6, and SLIT2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Corticospinal tract morphogenesis activity versus HMCN1 in CCRCC (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	HMCN1 →	+0.736	+0.073	<.001	<.001	3	7
BRCA	SERPINA6 →	+0.553	+0.041	<.001	<.001	3	6
OV	SLIT2 →	+0.575	+0.095	<.001	<.001	3	6
PDAC	HCCS →	-0.378	-0.059	<.001	<.001	3	6
CCRCC	LMCD1 →	+0.516	+0.055	.006	.004	3	6
BRCA	LRG1 →	+0.499	+0.035	.003	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021957 vs HMCN1 — CCRCC

Explore this scatter interactively →