Corticospinal tract morphogenesis

Across TCGA cell cohorts, RNA activity of the Corticospinal tract morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IFIT5, BORA, and LAS1L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IFIT5 grouped by Corticospinal tract morphogenesis-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	IFIT5 →	+2.347	+1.661	.001	<.001	3	4
LARGE_INTESTINE	BORA →	+0.653	+1.429	.001	<.001	3	4
BREAST	LAS1L →	+0.454	+0.738	.004	.004	3	4
LARGE_INTESTINE	CDC42BPB →	-1.355	-1.732	.006	<.001	3	4
LIVER	GIT1 →	+1.084	+1.661	<.001	<.001	3	3
LIVER	MORF4L2 →	+0.810	+1.661	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IFIT5 by Corticospinal tract morphogenesis activity — LIVER

Explore this box plot interactively →