Central nervous system neuron axonogenesis

Across TCGA patient cohorts, RNA activity of the Central nervous system neuron axonogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CCDC88B_S597, FMNL1_S184, and LCP2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Central nervous system neuron axonogenesis activity versus CCDC88B_S597 in LSCC (Pearson r = -0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CCDC88B_S597 →	-0.856	-0.073	<.001	<.001	3	6
LSCC	FMNL1_S184 →	-0.632	-0.038	<.001	<.001	3	6
GBM	LCP2 →	-0.420	-0.039	<.001	<.001	3	6
GBM	NCF2 →	-0.637	-0.038	<.001	.001	3	6
GBM	PTPN6 →	-0.529	-0.047	.001	<.001	3	6
GBM	PTPRC →	-0.649	-0.052	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021955 vs CCDC88B_S597 — LSCC

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