Central nervous system neuron development

Across TCGA patient cohorts, RNA activity of the Central nervous system neuron development pathway is significantly associated with the RNA expression of multiple genes, with the CHOL cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KAT6B, UBXN7, and SETD5, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Central nervous system neuron development activity versus KAT6B in CHOL (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	KAT6B →	+1.113	+0.050	<.001	<.001	3	33
DLBC	UBXN7 →	+1.371	+0.036	<.001	.002	3	33
DLBC	SETD5 →	+1.155	+0.046	<.001	<.001	2	34
DLBC	BRD3 →	+1.670	+0.055	<.001	.001	3	33
UVM	MGA →	+1.029	+0.028	<.001	<.001	3	33
THYM	NR2C2 →	+1.218	+0.038	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021954 vs KAT6B — CHOL

Explore this scatter interactively →