Central nervous system neuron development

Across TCGA patient cohorts, RNA activity of the Central nervous system neuron development pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IKZF1_S63, SASH3, and TAPBP, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Central nervous system neuron development activity versus IKZF1_S63 in GBM (Pearson r = -0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	IKZF1_S63 →	-0.799	-0.032	<.001	.009	3	7
HNSC	SASH3 →	-0.386	-0.045	<.001	<.001	3	6
BRCA	TAPBP →	-0.581	-0.017	<.001	<.001	3	6
HNSC	WDFY4 →	-0.452	-0.066	<.001	<.001	3	6
GBM	BIN2 →	-0.466	-0.036	.002	.002	3	6
GBM	PSMB10 →	-0.325	-0.031	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021954 vs IKZF1_S63 — GBM

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