Central nervous system neuron development

Across TCGA patient cohorts, RNA activity of the Central nervous system neuron development pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP2, NAV1, and MAP1A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Central nervous system neuron development activity versus MAP2 in HNSC (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MAP2 →	+1.445	+0.851	<.001	<.001	3	6
LSCC	NAV1 →	+0.846	+0.582	<.001	<.001	3	5
LSCC	MAP1A →	+0.763	+0.656	.001	<.001	3	5
LSCC	JAZF1 →	+0.463	+0.500	.001	.004	3	5
LSCC	PEAK1 →	+0.360	+0.789	.007	<.001	3	5
HNSC	CDH11 →	+0.633	+0.768	.007	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021954 vs MAP2 — HNSC

Explore this scatter interactively →