Central nervous system neuron development

Across TCGA cell cohorts, RNA activity of the Central nervous system neuron development pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABHD17A, MED16, and ZNF330, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Central nervous system neuron development activity versus ABHD17A in BREAST (Pearson r = -0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ABHD17A →	-0.619	-0.793	<.001	.001	2	5
UPPER_AERODIGESTIVE_TRACT	MED16 →	-0.964	-0.368	.002	<.001	3	4
LUNG_NSCLC_LUAD	ZNF330 →	-0.639	-0.699	.002	.009	3	4
LUNG_NSCLC_LUSC	MTR →	-0.618	-1.372	.007	<.001	3	4
LUNG_NSCLC_LUAD	SDE2 →	-0.406	-0.657	.001	<.001	3	4
SOFT_TISSUE	DNMT3A →	-1.760	-1.208	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021954 vs ABHD17A — BREAST

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