Central nervous system neuron differentiation

Across TCGA patient cohorts, RNA activity of the Central nervous system neuron differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PSMB10_S230, SEC23B, and CNPY4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Central nervous system neuron differentiation activity versus PSMB10_S230 in PDAC (Pearson r = -0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PSMB10_S230 →	-0.576	-0.035	<.001	<.001	3	7
PDAC	SEC23B →	-0.272	-0.032	<.001	<.001	3	6
OV	CNPY4 →	+0.365	+0.036	.003	<.001	3	6
HNSC	SEC24A →	-0.303	-0.036	<.001	<.001	3	6
BRCA	TAP1 →	-0.435	-0.019	<.001	<.001	3	6
BRCA	DDX21_S89 →	-1.245	-0.037	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021953 vs PSMB10_S230 — PDAC

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