Central nervous system neuron differentiation

Across TCGA cell cohorts, RNA activity of the Central nervous system neuron differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HDHD5, NME1, and BOLA3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Central nervous system neuron differentiation activity versus HDHD5 in LUNG_NSCLC_LUSC (Pearson r = -0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	HDHD5 →	-1.260	-0.303	<.001	.004	3	5
SOFT_TISSUE	NME1 →	-0.640	-1.783	.001	<.001	3	5
OESOPHAGUS	BOLA3 →	-0.963	-0.231	<.001	.002	3	4
SKIN	DARS2 →	-0.611	-0.698	<.001	.006	3	4
SKIN	RABEPK →	-0.474	-0.759	.005	.002	3	4
LARGE_INTESTINE	LYRM7 →	-0.636	-0.207	.004	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021953 vs HDHD5 — LUNG_NSCLC_LUSC

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