Central nervous system projection neuron axonogenesis

Across TCGA cell cohorts, RNA activity of the Central nervous system projection neuron axonogenesis pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMSB15A, FAM171A2, and HASPIN, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Central nervous system projection neuron axonogenesis activity versus TMSB15A in OVARY (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TMSB15A →	+3.668	+1.366	<.001	<.001	3	6
STOMACH	FAM171A2 →	+1.730	+1.043	.001	.001	3	6
BLOOD_Leukemia	HASPIN →	+1.071	+0.760	.003	.004	3	6
LUNG_NSCLC_LUAD	TCF19 →	+0.721	+0.754	.002	.001	3	5
STOMACH	EXOG →	+1.003	+0.956	.001	.007	3	5
BREAST	PSIP1 →	+1.023	+0.999	.005	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021952 vs TMSB15A — OVARY

Explore this scatter interactively →