Positive regulation of cerebellar granule cell precursor proliferation

pathway activity — cross-omics
GO:0021940Cross-omicsRNA → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Positive regulation of cerebellar granule cell precursor proliferation pathway is significantly associated with the RNA expression of multiple genes, with the SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMO, FGF2, and PTCH1, each associated with the pathway in up to 27 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
SCLCSMO →+2.219+1.191<.001<.001327
TGCTFGF2 →+1.707+0.131<.001<.001321
SARCPTCH1 →+1.252+0.071<.001<.001318
ESCAZNF853 →+1.803+0.142<.001<.001317
STADARHGEF25 →+1.228+0.122<.001<.001317
SARCCCDC8 →+1.987+0.086<.001<.001317
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration