Positive regulation of cerebellar granule cell precursor proliferation

pathway activity — cross-omics
GO:0021940Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Positive regulation of cerebellar granule cell precursor proliferation pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CASQ2, PGM5P4, and OXCT2P1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
PDACCASQ2 →+0.495+0.169.001<.00134
LSCCPGM5P4 →+0.449+0.439<.001.00334
OVOXCT2P1 →+0.552+0.305.003.00233
CCRCCPLCB4 →+1.103+0.546.001.00133
OVFGF2 →+1.605+0.422<.001<.00133
OVACER2P1 →+0.236+0.219.004.00633
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration