Hindbrain tangential cell migration

Across TCGA patient cohorts, RNA activity of the Hindbrain tangential cell migration pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EPHB2_S776, EPHB2, and CLIP2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hindbrain tangential cell migration activity versus EPHB2_S776 in LUAD (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	EPHB2_S776 →	+1.311	+0.109	<.001	<.001	3	8
LSCC	EPHB2 →	+0.523	+0.097	<.001	<.001	3	7
HNSC	CLIP2 →	+0.330	+0.103	<.001	<.001	3	5
LSCC	EML4 →	+0.127	+0.076	.008	<.001	3	5
LUAD	MAP1B_S1965 →	+0.552	+0.087	.001	<.001	2	6
PDAC	SLC4A2 →	-0.411	-0.067	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021934 vs EPHB2_S776 — LUAD

Explore this scatter interactively →