Hindbrain tangential cell migration

Across TCGA cell cohorts, RNA activity of the Hindbrain tangential cell migration pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP4K4, MORC4, and MAP3K11, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAP4K4 grouped by Hindbrain tangential cell migration-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	MAP4K4 →	+0.996	+0.181	.001	.003	3	4
PANCREAS	MORC4 →	+1.428	+0.265	.003	.008	3	4
KIDNEY	MAP3K11 →	+0.684	+0.784	.001	.008	3	4
BLOOD_Leukemia	NQO1 →	+1.216	+0.841	.006	<.001	3	3
BREAST	THAP4 →	+0.732	+0.673	<.001	.007	3	3
BREAST	SMAP2 →	+0.914	+0.746	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAP4K4 by Hindbrain tangential cell migration activity — OESOPHAGUS

Explore this box plot interactively →